Open Staff Positions
TECHNICAL ASSOCIATE II, Biological Engineering-Tal Group, to research comparative predictive diagnostics for infection-associated chronic illnesses (viral, bacterial, and fungal pathogens) through deep immunoinflammatory profiling. Will investigate antibody levels and ratiometric scores against key pathogen classes that may drive symptoms after infection; optimize flow-based immunoprofiling (FLIP) analysis for different pathogen targets and analyze antibody results; optimize, execute, and analyze/interpret high-resolution flow cytometry assays; perform Luminex antibody assays and analyze/interpret data; and culture Borrelia burgdorferi and execute in vitro experiments as needed. There will be occasional biobanking of clinical study participant samples and assisting with clinical study participant visits.
Description, requirements, and details on MIT HR Job Openings.
RESEARCH SCIENTIST 2, Biological Engineering-Synthetic Biology Center-Weiss Lab, to join an interdisciplinary research lab seeking to create integrated biological systems capable of autonomously performing tasks related to the activities of therapeutic agents for a variety of applications, including immunotherapy. Will participate in government- and corporate-sponsored research in mammalian synthetic biology, including genetically encoded therapies that perform cell type classification and conditionally administer appropriate therapeutic molecules. These mammalian genetic circuits will sense cell state, including miRNA levels, and implement multi-input logic regulating the expression of proinflammatory cytokines. Genetic circuits will be encoded on RNA replicons and distinguish between cell types such as lung cancer and T cells. Cell type identification will be based on determining an optimal combination of low and high miRNAs present or absent in the relevant cell types. Another level of control will be based on externally-administered small molecules that modulate the stability of regulatory RNA binding proteins. Will also engineer subgenomic promoters of RNA replicons for optimized tandem expression of constitutive and small molecule-regulated payloads in cancer and immune cells.
Description, requirements, and details on MIT HR Job Openings.
TECHNICAL ASSOCIATE I, Biological Engineering, to provide technical assistance on multiple high-impact projects in the research lab of Professor Katharina Ribbeck. These include the isolation and purification of mucus components for the development of assays to identify artificial sweeteners with superior flavor properties, the development of chemical profiling methods to identify properties of salivary mucus that mediate favorable sweetener perception, and the development of mucus-based assays to predict sweetener perception. Primary responsibilities will include developing and implementing biochemical protocols for mucin isolation from saliva, isolating and characterizing mucin-associated glycans, testing sweetener function in the context of mucus, and other tasks as assigned.
Description, requirements, and details on MIT HR Job Openings.
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